back color
Beneficial reconstitution of gut microbiome in children with Autism; paper in pre-print - Click Here
back color

Nichi-Glucan Refix is a biological response modifier beta glucan produced by N-163 strain of Aureobasidium pullulans, black yeast. It is an effective immunomodulator.


In pre-clinical studies, it has been proven to have potent anti-inflammatory and anti-fibrotic properties which is useful in conditions that involve a dysregulated metabolism and fibrosis such as Fatty liver disease or non-alcoholic steatohepatitis, liver cirrhosis etc. Its properties are further enhanced when it is taken along with Nichi Glucan (produced by AFO-202 strain of A. pullulans)

Publications of relevance:

Pushkala S, Seshayyan S, Theranirajan E, Sudhakar D, Raghavan K, Dedeepiya VD, Ikewaki N,Iwasaki M, Preethy S, Abraham S. Efficient control of IL-6, CRP and Ferritin in Covid-19 patients with two variants of Beta-1,3-1,6 glucans in combination, within 15 days in an open-label prospective clinical trial. medRxiv 2021.12.14.21267778; doi: 10.1101/2021.12.14.21267778

Ikewaki N, K Raghavan, V Suryaprakash, K Sharaf Rao, T Sonoda, Gary A. Levy, M Iwasaki, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham S. Beneficial Effects of novel Aureobasidium Pullulans strains produced Beta-1,3-1,6 Glucans on Interleukin-6 and D-Dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study. medRxiv 10.1101/2021.08.09.21261738v1; doi: 10.1101/2021.08.09.21261738

Ikewaki N, et al. Immune and metabolic beneficial effects of Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans in healthy middle-aged Japanese men: An exploratory study. medRxiv 2021.08.05.21261640; doi: 10.1101/2021.08.05.21261640

Ikewaki N, et al. Hepatoprotective effects of Aureobasidium pullulans derived Beta 1,3-1,6 biological response modifier glucans in a STAM- animal model of non-alcoholic steatohepatitis . bioRxiv 2021.07.08.451700; doi: 10.1101/2021.07.08.451700

Ikewaki N, et al. Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats..02 August 2021, PREPRINT (Version 1) available at Research Square; doi: 10.21203/

Ikewaki N, et al Beneficial effects of the AFO-202 and N-163 strains of Aureobasidium pullulans produced 1,3-1,6 beta glucans on non-esterified fatty acid levels in obese diabetic KKAy mice: A comparative study. bioRxiv 2021.07.22.453362; doi: 10.1101/2021.07.22.453362

* Links to publications are posted for educational purposes only.

Nichi Glucan range of products available in the brands, viz., Nichi Glucan, Nichi Glucan Refix, Neu-Refix and Nichi Glow are free from any of the following notified common allergens listed as per the Consumer Affairs Agency, Government of Japan.(Japanese)

Shrimp, crab, wheat, buckwheat, egg, milk, peanut (peanuts), Almond, abalone, squid, salmon roe, orange, cashew nut, kiwi fruit, beef, walnut, sesame, salmon, mackerel, soybean, chicken, banana, pork, matsutake mushroom, peach, yam, apple, gelatin.