back color
Beneficial reconstitution of gut microbiome in children with Autism; paper in pre-print - Click Here
back color

Nichi-Glucan Refix is a biological response modifier beta glucan produced by N-163 strain of Aureobasidium pullulans, black yeast. It is an effective immunomodulator.


In pre-clinical studies, it has been proven to have potent anti-inflammatory and anti-fibrotic properties which is useful in conditions that involve a dysregulated metabolism and fibrosis such as Fatty liver disease or non-alcoholic steatohepatitis, liver cirrhosis etc. Its properties are further enhanced when it is taken along with Nichi Glucan (produced by AFO-202 strain of A. pullulans)

Publications of relevance:

Ikewaki N, K Raghavan, V Suryaprakash, K Sharaf Rao, T Sonoda, Gary A. Levy, M Iwasaki, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham S. Beneficial Effects of novel Aureobasidium Pullulans strains produced Beta-1,3-1,6 Glucans on Interleukin-6 and D-Dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study. medRxiv 10.1101/2021.08.09.21261738v1; doi: 10.1101/2021.08.09.21261738

Ikewaki N, et al. Immune and metabolic beneficial effects of Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans in healthy middle-aged Japanese men: An exploratory study. medRxiv 2021.08.05.21261640; doi: 10.1101/2021.08.05.21261640

Ikewaki N, et al. Hepatoprotective effects of Aureobasidium pullulans derived Beta 1,3-1,6 biological response modifier glucans in a STAM- animal model of non-alcoholic steatohepatitis . bioRxiv 2021.07.08.451700; doi: 10.1101/2021.07.08.451700

Ikewaki N, et al. Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats..02 August 2021, PREPRINT (Version 1) available at Research Square; doi: 10.21203/

Ikewaki N, et al Beneficial effects of the AFO-202 and N-163 strains of Aureobasidium pullulans produced 1,3-1,6 beta glucans on non-esterified fatty acid levels in obese diabetic KKAy mice: A comparative study. bioRxiv 2021.07.22.453362; doi: 10.1101/2021.07.22.453362